Guowei Wei has pioneered novel computational methods that integrate profound mathematical structures with deep learning, leading to victories in worldwide drug design competitions and the discovery of SARS-CoV-2 evolutionary mechanisms. He has earned numerous awards and honors, including the fellowship of AIMBE. In addition, he collaborates with premier pharmaceutical companies on drug discovery. Wei has served extensively on various national and international panels, committees, and journal editorships. Many of his former trainees now hold faculty positions in research universities worldwide. Wei received his doctorate from the University of British Columbia and currently holds the position of MSU Foundation Professor of Mathematics at Michigan State University.